Sodium Channels, Pain, and Analgesia (Progress in Inflammation Research)
by Kevin Coward and Mark D. Baker
Sales Rank: 2557763
List Price: $159.00 $159.00 At Amazon
Hardcover: 199 pages
Publisher: Birkhäuser Basel; 1 edition September 13, 2005
Language: English
ISBN-10: 3764370629
ISBN-13: 978-3764370626
Product Dimensions:
9.2 x 6.4 x 0.6 inches
Shipping Weight: 1.4 pounds
Product Description
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme.
Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.
